Quantum dot optic microcavity device had potential application in field of quantum information technology using as the low threshold laser and single photon light source etc. High density of quantum dot need be implanted into the glass microsphere with high dielectric constants in order to realize the optic gain and lasing. The glass formation ability, infrared, crystallization thermal stability and microcavity forming ability in the ZnO-P2O5, CdO-P2O5 and CdS-P2O5 binary phosphate glass system were investigated. The maximum solubility of ZnO in the glass is 0.6 mole fraction, and that of CdO and CdS is 0.4 mole fraction. The glass matrices have a similar light absorption character to those commercial cut-off filter glass, which was not dependent on the composition of the glass. The α-Zn2P2O7 or CdS solid phase was precipitated in the crystallized glass matrices, where CdS phase has a uniform distribution in matrices. The powdered glass matrices can easily be formed into microcavity with a perfectly round sphere using thermal spray method. It was concluded that the ZnO-P2O5 and CdS-P2O5 binary phosphate glass can be formed into optic microcavity and the high density of Ⅱ-Ⅵ group quantum dot can grow in CdS-P2O5 glass matrices.