. (A) Transmission electron micrograph images of Al-L (a) and Al-H (b, c); (B) Atomic force microscopy image of Al-H; (C) N₂ sorption isotherms and pore size distribution curves of the samples; (D) XRD patterns of the samples; (E) The release curves of Dox for the AlOOH NSs

. (A) Confocal laser scanning micrographs of cellular uptake of Al-H/Dox samples by DU145 cells after coculture for 0.5 (a), 2.5 (b) and 24 h (c); (B) Histogram and (C) quantitative results of Dox cellular uptake efficiency (E%) by DU145 cells incubated for 2 h with (a) control, (b) Al-L/Dox at 5 μg/mL of particles, (c) Al-H/Dox at 5 μg/mL of particles, and (d) free Dox with an equivalent amount of Dox loaded onto Al-H/Dox samples

. Percentage of apoptosis and necrosis in DU145 cells treated with control (A), Al-L/Dox at 25 μg/mL (B), or Al-H/Dox at 25 μg/mL (C) for 1 d; Free Dox with an equivalent amount of Dox released from Al-H/Dox after 1 d at pH 5 was used as contrast (D)

. Blood biochemistry analysis (A-E) of mice after intravenous administration with Al-H (n=3)

. Formation of AlOOH NSs, loading of chemotherapy drugs onto NSs, and intravenous injection of the as-prepared NSs