• Laser & Optoelectronics Progress
  • Vol. 59, Issue 1, 0100004 (2022)
Anjun Zhang1, Jialin Duan2、*, Yingbin Xing1, and Jinyan Li1、**
Author Affiliations
  • 1Wuhan National Research Center for Optoelectronics, Huazhong University of Science and Technology, Wuhan , Hubei 430074, China
  • 2Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , Hubei 430074, China
  • show less
    DOI: 10.3788/LOP202259.0100004 Cite this Article Set citation alerts
    Anjun Zhang, Jialin Duan, Yingbin Xing, Jinyan Li. Application of Thulium-Doped Laser in the Biomedicine Field[J]. Laser & Optoelectronics Progress, 2022, 59(1): 0100004 Copy Citation Text show less
    Distribution diagram of heat affected areas [11]
    Fig. 1. Distribution diagram of heat affected areas [11]
    Comparison of suture results of continuous and modulated thulium-doped laser tissue under different powers and operation time [21]
    Fig. 2. Comparison of suture results of continuous and modulated thulium-doped laser tissue under different powers and operation time [21]
    Structure diagram of in vitro experimental device[26]
    Fig. 3. Structure diagram of in vitro experimental device[26]
    Cross-sections of vein tissues before and after surgery. (a) Cross-section of tissue before surgery; (b) rough diagram of tissue cross-section with output power of 3 W; (c) rough diagram tissue cross-section with output power of 1.5 W; (d) tissue cross-section with output power of 4 W; (e) detail view of tissue cross-section with output power of 3 W; (f) detail view of tissue cross-section with output power of 1.5 W[39]
    Fig. 4. Cross-sections of vein tissues before and after surgery. (a) Cross-section of tissue before surgery; (b) rough diagram of tissue cross-section with output power of 3 W; (c) rough diagram tissue cross-section with output power of 1.5 W; (d) tissue cross-section with output power of 4 W; (e) detail view of tissue cross-section with output power of 3 W; (f) detail view of tissue cross-section with output power of 1.5 W[39]
    Lithotripsy efficiency when pulse energy of Tm-doped laser is 35 mJ[29]. (a) Relationship between pulse frequency and lithotripsy efficiency; (b) relationship between pulse frequency and crushing stone repulsion distance
    Fig. 5. Lithotripsy efficiency when pulse energy of Tm-doped laser is 35 mJ[29]. (a) Relationship between pulse frequency and lithotripsy efficiency; (b) relationship between pulse frequency and crushing stone repulsion distance
    Comparison of lithotripsy efficiency between thulium-doped laser and holmium-doped laser with the same laser parameters [31]
    Fig. 6. Comparison of lithotripsy efficiency between thulium-doped laser and holmium-doped laser with the same laser parameters [31]
    YearGain mediumWavelength /μmModeAverage power /WSingle pulse energyFrequency /HzPulse widthOperationMaterialReference
    1999Thulium fiber1.88‒2.033CW5Tissue ablationChicken breast7
    2003Tm∶YAG2.013CW10‒60Tissue ablationPorcine liver26
    2003Thulium fiber1.99CW /modulation0.2100‒1.7×104150‒900 nsTissue ablationChicken breast,lamb liver,and cartilage27
    2007Tm∶YAG2.013CW4Tissue ablationExcised calf larynges28
    2010Tm∶YAG2CW15Tissue ablationPorcine abdominal6
    2011Thulium fiber1.908CW /modulation35‒175 mJ10‒400500 μsLithotripsyCOM29
    2011Tm∶YAP1.98CW0.2Tissue ablationWistar rat brain tissue30
    2014Thulium fiber1.908CW /modulation35 mJ150‒500500 μsLithotripsyCOM31
    2014Tm∶YAG1.94CW /modulation10000.4‒1.4 msTissue ablationPorcine kidney32
    2015LiYF4∶Tm1.885CW2.8‒3Endovenous laser ablationGreat saphenous veins33
    2016Thulium fiber1.94CW /modulation9.5100‒100040 μs‒2 sLithotripsyCOM34
    2016Thulium fiber1.942CW /modulation0.4‒2105160‒400 nsTissue ablationChicken breast porcine spinal cord35
    2016Thulium fiber1.94CW /modulation0.2‒0.8Tissue ablationLamb liver11
    2017Thulium fiber1.94CWLithotripsyCOM31
    2018Tm∶YAG2CW1‒7Endoscopic third ventriculostomyGelatin36
    2018Tm∶YAG2CW60Tissue cuttingBones37
    2018Thulium fiber1.94CW /modulation60‒90Tissue ablationDog prostate38
    2019LiYF4∶Tm1.91CW3‒4Endovenous laser ablationSaphenous veins39
    2018Thulium fiber1.92CW4Endovenous laser ablationGreat saphenous veins40
    2019Thulium fiber1.94CW/modulation10‒320.2‒0.4 J50‒800.5‒1 nsLithotripsyCOM41
    2019Thulium fiber1.94CW0.4‒0.6Tissue ablationWistar rat brain tissue42
    2020Thulium fiber1.94CW/modulation14‒3630500‒1000 μsTissue cuttingPorcine kidney43
    2020Thulium fiber1.94CW/modulation0.4‒0.6Tissue ablationWistar rat brain tissue44
    Table 1. Tm-doped laser biomedical experiment
    YearLight sourceWavelength /μmLaser power /WOperationCasesReference
    2006Revolix2.0134Microlaryngeal7424
    2009Revolix270/120Benign prostatic hyperplasia5645
    2011Revolix2Benign prostatic hyperplasia3646
    2012Revolix28‒15Neuroendoscopic intraventricular4447
    2012Revolix2.0134Dissection of laryngeal soft tissue4548
    2013Quanta system2.0140Pulmonary lobectomy4049
    2013Revolix2.0131‒7Removal of intracranial meningiomas2050
    2014Revolix2.0137‒19Oral squamous cell carcinomas4225
    2014Vela XL1.943‒9Endovenous laser ablation5523
    2016Revolix1.9120Benign prostatic hyperplasia8151
    2016Medilaser DMC1.943‒7Endovenous laser ablation3752
    2016IPG1.94Endovenous laser ablation13853
    2017Tianjin Tiankun270/120Benign prostatic hyperplasia24854
    2017Revolix240‒50Partial nephrectomy6055
    2018Revolix2120Benign prostatic hyperplasia6056
    2018Revolix21‒7Endoscopic third ventriculostomy10636
    2019Unknown1.944Endovenous laser ablation8957
    2019IPG1.9410‒50Lithotripsy26822
    Table 2. Clinical application of thulium-doped laser
    TissueType of laserAverage power /mWTime /sHole depth /μmAffected zone width /μm
    Chicken breastCW1502039800
    Q-switch(100 Hz)15020100160
    Sheep liverCW14030100400
    Q-switch(1 kHz)14030200120
    Table 3. Experimental results of continuous and Q-switched lasers on chicken breast and sheep liver [27]
    LaserFrequency /HzLaser time /sPeak temperature /℃Operation time /s
    Ho∶YAG6167±4124±1207±50
    Tm∶YAG150111±4933±3116±54
    30039±1133±754±22
    50023±439±660±22
    Table 4. Comparison of different frequencies of Tm-doped laser and Ho-doped laser, laser working time, operating time, and salt water temperature [67]
    Anjun Zhang, Jialin Duan, Yingbin Xing, Jinyan Li. Application of Thulium-Doped Laser in the Biomedicine Field[J]. Laser & Optoelectronics Progress, 2022, 59(1): 0100004
    Download Citation