Metal-organic frameworks (MOF) as piezoelectrical materials used in mechano-catalytic degradation of organic dye are rarely investigated. In this work, NH₂-UiO-66 was synthesized by the solvothermal method and applied in mechano-catalytic degradation of Rhodamine B under ultrasonic vibration. The results show that NH₂- UiO-66 behaves a high mechano-catalytic decomposition efficiency of 80% for Rhodamine B within 5 h vibration and possesses a good stability. The piezoelectrically induced electric charges on the surfaces of NH₂-UiO-66 via the piezoelectric effect could induce hydroxyl radicals as strong oxidants to decompose Rhodamine B. The piezoelectrical effect of MOFs is potential in utilizing vibration energy for dye wastewater treatment.