• Journal of Inorganic Materials
  • Vol. 35, Issue 10, 1163 (2020)
Long GAO1、2, Zhaowenbin ZHANG1、2, and Jiang CHANG1、2、*
Author Affiliations
  • 1Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
  • 2University of Chinese Academy of Sciences, Beijing 100049, China
  • show less
    DOI: 10.15541/jim20190593 Cite this Article
    Long GAO, Zhaowenbin ZHANG, Jiang CHANG. Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers[J]. Journal of Inorganic Materials, 2020, 35(10): 1163 Copy Citation Text show less

    Abstract

    Porous microsphere cell microcarrier with macroporous structure can not only amplify cells in vitro, but also serve as cell delivery tools to deliver cells to damaged tissues by injection. Bioglass (BG) is an inorganic material with excellent biological activity, however, it is difficult to directly prepare microcarriers with macroporous structure. Therefore, in this study, a BG/poly-lactic acid (PLA) porous microspheres was prepared by double emulsion method. The morphology and structure of the microsphere were characterized by SEM, and the load of BG in the microsphere was characterized by thermo gravimetric analysis and its ion release was detected by ICP. Cell proliferation experiments showed that cells could adhere and grow on the surface and inside of the microspheres. The results show that the microsphere with interconnected open-pore microstructure is suit for cell adhesion and proliferation. Bioglass can promote cell proliferation in the microspheres and the obtained BG/PLA composite microsphere has great potential applications in tissue engineering.
    Long GAO, Zhaowenbin ZHANG, Jiang CHANG. Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers[J]. Journal of Inorganic Materials, 2020, 35(10): 1163
    Download Citation