Based on the working principle of laser mouse, the digital speckle correlation method is used to realize orientation of laser mouse. The orientation principle is investigated. The experiment is designed to obtain the speckle pattern by a digital camera. The CCD is used to scan the moving spackle picture through the image acquisition board. Two parameters of optimum sampling, pixel and image displacement, are obtained by data analysis. The speckle picture is moved by a definite trace and shot by a digital camera, and the experiment is simulated by solfware Matlab. The displacement of speckle picture is processed by digital speckle correlation method. The simulated results are compared with the experimental results. The results prove the digital speckle correlation method can confirm allocation, and the obtained resolution is 1 μm, which is higher than the resolution 30 μm of the laser mouse in market.