An adaptive slope compensation circuit for boost converter was designed. By dynamically detecting the input and output voltages of the boost converter, the circuit generated a ramp voltage following the duty cycle, and optimized the compensation slope. Due to the high-precision subtractor, the slope compensation accuracy was improved to minimize the adverse impact of compensation to the boost converter while eliminating the sub-harmonic oscillations and improving the stability of the boost converter, with little impact on the load capacity and dynamic response speed. The circuit was designed in SMIC 0.18 μm process. The post simulation results show that, under different working conditions, the compensation slope can be adaptively adjusted with the duty cycle at an operating voltage of 3.3 V, and the error to the theoretical compensation slope is 1.39%~2.33%.