A method of improving image reconstruction quality for time-domain breast diffuse optical tomography is proposed based on panel detection. A measurement space expanded scheme is presented that uses cubic spline interpolation to obtain more measurements from less source-detector pairings to alleviate the problem that the number of boundary measurements data is generally far fewer than that of unknown parameters to be reconstructed in reconstructing process. Compared with traditional algorithm, this method can efficiently improve the reconstruction quality and spatial resolution. The proposed methodology is validated by reconstructing the image of the slab phantom containing two deeply-located absorption and scattering contrasting cubes. And the reconstruction contrast is analysed here for the quantification of the spatial resolution.Numerical simulation results illustrate that the spatial resolution of reconstructed image is 4 mm edge-to-edge.