Author Affiliations
1Guangdong Province Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education,College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China2Health Science Center, Shenzhen University, Shenzhen 518060, Chinashow less
Fig. 1. Diagram of BPD structure of liposome
Fig. 2. Different aggregation states of Aβ solution. (a) Aβ fibers; (b) Aβ spherulites; (c) Aβ plaques
Fig. 3. Absorption and fluorescence emission spectra of BPD solution with different mass concentrations. (a) BPD ultraviolet absorption spectra; (b) standard curve of BPD absorbance varying with mass concentration; (c) BPD fluorescence emission spectra; (d) standard curve of BPD fluorescence intensity varying with mass concentration
Fig. 4. Degradation mechanism of Aβ aggregates by BPD and its liposomes
Fig. 5. Degradation results of Aβ plaques with only irradiation. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images
Fig. 6. Degradation results of Aβ plaques after irradiation when the concentration of BPD is 1 μmol/L. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images
Fig. 7. Degradation results of Aβ plaques after irradiation when the concentration of BPD is 10 μmol/L. (a)(e)(i)(m) Bright field images; (b)(f)(j)(n) confocal images; (c)(g)(k)(o) second harmonic generation images; (d)(h)(l)(p) two photon excited fluorescence images
Fig. 8. Relationship between fluorescence intensity of Aβ plaques and irradiation time
Fig. 9. Degradation results of Aβ plaques after irradiation when the concentration of BPD is 100 μmol/L. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images
Fig. 10. Relationship between degradation efficiency of Aβplaques and concentration of BPD
Fig. 11. ELISA detection results of Aβ content after irradiation with different doses
Fig. 12. Degradation results of Aβ plaques after irradiation with BPD liposome. (a)(e) Bright field images; (b)(f) confocal images; (c)(g) second harmonic generation images; (d)(h) two photon excited fluorescence images