Photonic crystal is an artificial dielectric material whose dielectric constant changes periodically. It has two important features: photonic band gap and photon localization. Photonic crystal waveguide transmits light signal using photonic band gap. Compared with conventional strip waveguide, the most significant advantage of photonic crystal waveguide is that there is very little transmission loss at the corner (the loss can be decreased to about 5% at the corner of 60°). Therefore, photonic crystal waveguide has important applications in the field of integrated optics. In this paper, we start with the features of chalcogenide glass, and introduce two types of methods in fabricating photonic crystal waveguides of chalcogenide glass. Through these two fabrication methods, photonic crystal waveguides can be obtained with both high quality of surfaces and low transmission loss. The differences between the two methods are also compared and the applications of the photonic crystal waveguide based on chalcogenide glass are introduced. Finally, the prospects of the photonic crystal waveguide based on chalcogenide glass are put forward.