The performance of CCD, such as readout noise, determines the final data quality of satellite X-ray detection payload. Commercial CCD sensor cannot be applied in space, neither in X-ray detection. The structure of an X-ray sensing CCD was explained, taking E2V space qualified product for example. Drive circuit met the time and voltage demand was designed with FPGA and an integrated drive circuit. CCD signal was amplified and filtered by a gain adjustable CCD signal process circuit. The calibration methods of gain and readout noise using Fe55 radioactive sources are also described. The measured gain of CCD and its support circuit is 5.1 e-/DN, and the readout noise is 37 e-.