The ablation effect of the combined continuous wave (CW) and pulsed lasers on metal targets is better than that of single CW or pulsed lasers. To optimize the parameter selection of the combined action of CW and pulsed lasers, both the experimental and simulation methods are used to study the influence of irradiation time sequence on damage effectiveness of the combined lasers. The results denote that the combined laser brings the best damage effectiveness when the pulsed laser irradiates during CW laser irradiation. The combined laser considerably reduces the damage time and increases the ablation range. Furthermore, the longer the preheating time, the larger the damage range. In case of the combined lasers, wastage of laser energy is observed if the energy of the long laser pulse becomes considerably high. Therefore, it is essential to select reasonable parameters for energy matching of CW laser power and long pulsed laser.