As one of the foundational tools for constructing cryptographic protocols, zero-knowledge proof is widely applied in the field of information security. The classical zero-knowledge proof scheme is based on computational complexity theory in mathematics, and its security is seriously threatened with the continuous improvement of computing power, especially the appearance of quantum computer etc. A zero-knowledge proof protocol is proposed based on quantum teleportation principle. The proposed protocol uses quantum physical characteristics to implement zero-knowledge proof. It has the unconditional security, and can defeat all kinds of possible quantum attacks.