A micro-fabrication method for thin nickel plates was explored by Wire-cut Electrical Discharge Machining (WEDM).A series of experiments of WEDM for the meso-scale structure of a thin nickel plate with a thickness of 0.6 mm were carried out. Then, a trial cutting test was performed using existing machining parameters in the machine, and the dimensional accuracy and surface quality of the thin nickel plate after cutting were measured and analyzed. On that basis, the machining process was improved by changing the discharge energy, flushing pressure and the cutting speed. The method of multiple cutting within a 200 μm narrow slit was discussed as well, and reasonable optimization and merger for cutting times were carried out. Experimental results indicate that the WEDM can cut the meso-scale structure with a thickness less than that of machine original setting in steady for the thin nickel plate. The surface quality can be improved after multiple cutting for the 200 μm narrow slit, and the final surface roughness Ra is 0.54 μm after fifth cutting. With the machining surface quality guaranteed, the final surface roughness Ra is 0.62 μm when the cutting times are merged from 5 into 3, by which the machining time is shortened by 30%.The method proposed can also apply to meso-scale structures of other materials.