A method is proposed for multi-spectral image compression based on rectangle region of interest (ROI) coding of EBCOT, which does not lift the coefficients of wavelet domain and is complemented by code stream organization. When the code stream is organized, the distortion of ROI can be calculated approximately, which is used to adjust the code stream organization to meet the need of the peak signal-to-noise ratio (PSNR) of ROI. This procedure is adaptive. The decoder needs not to lift reversely the coefficients and works normally. If the distortion requirement is changed, the organization can be done again, but the T1 coding of EBCOT needs not be done again, so the algorithm is more efficient and more flexible. A fast computation of the slopes is proposed, by which not only the precision of the slopes is enough but also the floating point division and floating point expression of the slopes are avoided, so the system complexity is decreased. This method is suitable for multi-spectral image compression.