Through analysis of solar azimuth of Chang’E-1 IIM data, the data of high-angle were chosen to do radiometric calibration. The method of neighbourhood averaging and neighbourhood weighted averaging were adopted to repaire original data which contains bad points and bands. Because of interference imaging spectrometer’s inherent problem and CCD array gain distortion, the image displays discontinuity of transverse response. By using the method of subspace maximum eigenvalue to cablibrate image, the statistical result of processed images shows homogeneity on intensity of radiance. The empirical linear method was adopted to calibrate IIM data absolutely. Meanwhile, in order to correct bias coefficient of data which has been calibrated and de-noised , the method of wavelet transform was adopted to modificate data of radiometric calibration for the first time, the final available IIM 2C data were confirmed. Compared with the data which has been accredited, the analysis proposal of IIM 2C data was established. Then the first reflectivity image of the lunar nearside based on Chang’E-1 IIM 2C was accomplished .