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    Journals >Laser & Optoelectronics Progress >Volume 58 >Issue 1 >Page 117001 > Article
    • Laser & Optoelectronics Progress
    • Vol. 58, Issue 1, 117001 (2021)
    Study on Synovial Arthritis Based on Surface-Enhanced Raman Scattering Spectroscopy
    Dong Xianhu1, Tang Shuzhen1, Chen Sunyu2、*, Xu Jianshu1, Lin Yamin1, Gao Siqi1, Zhong Haoran1, Lin Tingting1, and Gao Jiamin1
    Author Affiliations
  • 1MOE of Key Laboratory of Opto-Electronic Science and Technology for Medicine, Fujian Provincial Key Laboratory for Photonics Technology, College of Photonic and Electronic Engineering of Fujian Normal University, Fuzhou, Fujian 350007, China
  • 2Department of Orthopaedics, Affiliated Fuzhou the Second Hospital of Xiamen University, Fuzhou, Fujian 350007, China
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    DOI: 10.3788/LOP202158.0117001 Cite this Article Set citation alerts
    Dong Xianhu, Tang Shuzhen, Chen Sunyu, Xu Jianshu, Lin Yamin, Gao Siqi, Zhong Haoran, Lin Tingting, Gao Jiamin. Study on Synovial Arthritis Based on Surface-Enhanced Raman Scattering Spectroscopy[J]. Laser & Optoelectronics Progress, 2021, 58(1): 117001 Copy Citation Text show less
    SERS average spectra and different spectra of joint fluid from arthritis patients(n=18) and normal people(n=15)
    Fig. 1. SERS average spectra and different spectra of joint fluid from arthritis patients(n=18) and normal people(n=15)
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    Posterior probability and ROC curves.(a) Posterior probability scatter of SERS spectra of joint fluid from arthritis patients and normal people based on PCA-LDA analysis and cross-validation method; (b) ROC curves under different identification thresholds
    Fig. 2. Posterior probability and ROC curves.(a) Posterior probability scatter of SERS spectra of joint fluid from arthritis patients and normal people based on PCA-LDA analysis and cross-validation method; (b) ROC curves under different identification thresholds
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    Three-dimensional scatter plot of SERS spectra of joint fluid from arthritis patients (dot) and normal people (pentagram) based on PCA-LDA analysis and cross-validation method
    Fig. 3. Three-dimensional scatter plot of SERS spectra of joint fluid from arthritis patients (dot) and normal people (pentagram) based on PCA-LDA analysis and cross-validation method
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    Peak position /cm-1Tentative assignment
    477Polysaccharides
    490Glycogen
    596Phosphatidylinositol
    640C-S stretching & C-C twisting of proteins tyrosine
    722DNA
    1071Glucose
    1439δ (CH2)(lipids)
    1576Guanine(N3)
    1645Amide I
    1676Amide I
    Table 1. Raman peak positions and tentative assignments[19-27]
    Abstract
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    Dong Xianhu, Tang Shuzhen, Chen Sunyu, Xu Jianshu, Lin Yamin, Gao Siqi, Zhong Haoran, Lin Tingting, Gao Jiamin. Study on Synovial Arthritis Based on Surface-Enhanced Raman Scattering Spectroscopy[J]. Laser & Optoelectronics Progress, 2021, 58(1): 117001
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