Ke Wang, Lei Zheng, Mengyuan Qin, Wanjian Zhang, Xiangquan Deng, Shen Tong, Hui Cheng, Jie Huang, Jincheng Zhong, Yingxian Zhang, Ping Qiu. Aberration correction for multiphoton microscopy using covariance matrix adaptation evolution strategy[J]. Chinese Optics Letters, 2023, 21(5): 051701
- Chinese Optics Letters
- Vol. 21, Issue 5, 051701 (2023)
Fig. 1. Experimental setup. L1, f = 100 mm lens; L2, f = 75 mm lens; LPF, 1650-nm long-pass filter; HWP, half-wave plate; PBS, polarization beam splitter cube; L3, f = 35 mm lens; L4, f = 150 mm lens; L5, f = 500 mm lens; L6, f = 150 mm lens; DC, dichroic mirror; OL, objective lens; BPF, bandpass filter.
Fig. 2. Simulation process schematic. (a) The GA process schematic, and (b) the CMA-ES process schematic.
Fig. 3. Comparison of the GA and the CMA-ES by numerical simulation. (a) The original aberrated wavefront (left), the wavefront corrected by GA (middle), and the wavefront corrected by CMA-ES (right). (b) The iteration curve comparison.
Fig. 4. System aberration correction results. (a) The comparison of the fluorescent bead before and after corrections (left, without correction; middle, correction by GA; right, correction by CMA-ES). (b) The axial resolution comparison. (c) The iteration curve comparison.
Fig. 5. Brain slice aberration correction result. (a) The Brain slice THG image (left, without correction; middle, correction by GA; right, correction by CMA-ES). (b) The line profile of the underlined THG signal in (a). (c) The comparison of the iteration curves.
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