A novel quasi-crystal microcavity slab laser is designed based on conjugated polymer MEH-PPV with excellent optical-electrical properties and the modulation of quasicrystal microcavity. The MEH-PPV is applied as the gain medium and achieve electrical-pumping 8-fold quasicrystal vertical-cavity surface-emitting laser based on the confinement of point-defect photonic crystal structure and the reflection between anode and cathode in the vertical direction. The current threshold of laser is 0.8 mA, and the lasing action occurs at λ = 606 nm with a full width at half maximum (FWHM) of 0.5 nm, limited by the resolution of the spectrometer.