Insulated gate bipolar transistor (IGBT) drive protection circuit is taken as the interface circuit between the inverter main circuit and the control circuit. It is very important for the inverter to design a good drive protection circuit in normal operation. Traditional inverter drive circuits only rely on software to set the dead zone protection time to avoid the phenomenon that the up bridge and down bridge of the same phase simultaneously turned. Through this circuit, once the software runs error, it is likely to cause the IGBT up bridge and down bridge simultaneously turned and blows up the inverter. A new inverter drive circuit with hardware interlock function is described. In this new drive circuit, the inverter bridge drive opto-coupler is driven by a group of differential pulse width modulation (PWM) signal. The two opto-couplers for the up bridge and down bridge of the same phase bridge arm in the driving circuit are driven by the same group opposite logic differential PWM signal. The hardware interlock function of the inverse bridge drive circuit is realized to avoid the phenomenon of both the up and down bridge simultaneously turned and the reliability of the inverter drive circuit is improved greatly.