Chalcogenide glass photonic crystal fiber is expected to have important applications in the field of mid-infrared laser transmission. The Ge30Sb8Se62 chalcogenide glass with excellent transparency in mid-infrared region is prepared. Based on this chalcogenide glass, a band-gap photonic crystal fiber is designed, which suits high power laser transmission. With plane wave expansion method and finite element method, photonic band gap, mode-field area and confinement loss of the designed photonic crystal fiber are systematically studied. By optimizing the structural parameters of fiber, photonic crystal fiber with confinement loss less than 0.1 dB/m and effective mode-field area larger than 100 μm2 at 10.6 μm is obtained.