Artificial infrared irradiation has an effective interference on correlation tracking by changing the infrared characteristics of target and background, where the location of infrared irradiation has an important impact on the interference performance. In order to improve the interference efficiency, the model of searching interference points by using infrared irradiation simulation was established. First, the infrared irradiation model in the true experimental environment was built in TracePro and the illuminance distribution of irradiation spot was fitted by Gaussian model. Then, the experiments with true irradiation condition and simulation irradiation condition were carried out. The comparison experiments show that the interference results of different irradiation locations under the two conditions are uniform in 98% and all interference points are found by irradiation simulation, illustrating the effectiveness of the proposed method in the paper.