Strong absorption of 980 nm wavelength light by biological tissues results in the limited application of Yb/Er or Yb/Tm doped NaYF4 upconversion nanoparticles.800 nm excited NaYF4∶Yb,Er/Tm nanoparticles doped with Nd3 + ions are reported.By comparing the photoluminescence spectra of different structured nanoparticles incorporated with Nd3 + ions,it is found that the emission intensity by 800 nm laser of core/shell structured NaYF4∶Yb3 + 20%,Er3 + 2%@NaYF4∶Nd3 + 20% nanoparticles is the highest,which is close to the emission intensity of NaYF4∶Yb3 + 20% ,Er3 + 2% nanoparticles excited by 980 nm laser.The emission intensity is enhanced by more than 600 times compared with that of NaYF4∶Yb3 + 20%,Er3 + 2%,Nd3 + 20% nanoparticles.It is proved that the quench effect due to Nd incorporation is mainly related to the interaction between Nd3 + ions and the sensitizer Yb3+ ions,but not that between Nd3+ ions and the activator Er3+/Tm3+ ions.