To improve the microstructures and properties of Ni-based laser cladding layers, the Ni-based laser cladding layers with different mass fractions of nano TiO2 and CeO2 are prepared on the Q235 steel substrate surfaces by the synchronous feeding of laser cladding powder. The surface morphologies, microstructures and phase compositions of laser cladding layers are analyzed and the microhardness and corrosion resistance of laser cladding layers are measured as well. The research results show that the simultaneous addition of TiO2 and CeO2 in the Ni-based alloy powder can fully integrate the properties of both and make well-distributed, fine, crack-free and corrosion-resistant laser cladding layers obtained.