Nowadays, cell phone lens is developing towards high resolution, large aperture and ultra-thin thickness. According to the design requirement of cell phone lens, we study the relationship between the design parameters and constrain conditions and objective function in Delano diagram. With the Mente Carlo-particle swarm optimization (PSO) hybrid optimization algorithm, the automatic generation of the cell phone lens initial configuration is realized. Taking the proposed method, we design a 5 pieces-twenty million pixels and ultra-thin tele-lens of cell phone. The design results show that the modulation transfer function (MTF) is greater than 60% within 0.8 field of view at the 1/4 Nyquist frequency 125 lp/mm. Compared with the 6 pieces lens with the same design requirement parameters, which is based on PWC method, the yield rate is increased by 10% at the edge of view by the tolerance simulation. By the TV line test of the 5 pieces-twenty million pixels lens after the fabrication, the resolving power of 2300 LW/PH and 1700 LW/PH at the centre and the 0.8 field of view are obtained. The outcome of design, manufacturing and TV line test show that, the solving method of initial configuration for cell phone lens based on Delano diagram can help to improve the design efficiency and get higher yield.