Researching | Preclinical evaluation of osteogenic effects of 99Tc-MDP in osteoporosis models

Journals >NUCLEAR TECHNIQUES >Volume 48 >Issue 3 >Page 030302 > Article

NUCLEAR TECHNIQUES
Vol. 48, Issue 3, 030302 (2025)

Preclinical evaluation of osteogenic effects of ⁹⁹Tc-MDP in osteoporosis models

Shengnan REN, Linlin LI, Yun ZHANG, Yaling ZHOU..., Tao JIANG, Kejia GAO^* and Fang FENG^*|Show fewer author(s)

Author Affiliations

Department of Nuclear Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China

show less

DOI: 10.11889/j.0253-3219.2025.hjs.48.240124 Cite this Article

Shengnan REN, Linlin LI, Yun ZHANG, Yaling ZHOU, Tao JIANG, Kejia GAO, Fang FENG. Preclinical evaluation of osteogenic effects of ⁹⁹Tc-MDP in osteoporosis models[J]. NUCLEAR TECHNIQUES, 2025, 48(3): 030302 Copy Citation Text

show less

References

[1] Seriolo B, Paolino S, Casabella A et al. Osteoporosis in the elderly[J]. Aging Clinical and Experimental Research, 25, 27-29(2013).

[2] Thommesen L, Stunes A K, Monjo M et al. Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism[J]. Journal of Cellular Biochemistry, 99, 824-834(2006).

[3] LOU Jingjing, LI Tongtong, LIU Xingdang et al. Recent progress of nuclear medicine evaluation of curative effect of 223Ra dichloride treatment on castration- resistant prostate cancer and bone metastases[J]. Nuclear Techniques, 44, 120301(2021).

[4] Shi L J, Ning Y, Xu L L et al. Technetium-99 conjugated with methylene diphosphonate ameliorates glucocorticoid induced osteoporosis by inhibiting osteoclastogenesis[J]. BioMed Research International, 2018, 7902760(2018).

[5] Xie J H, Yuan X Y, Mao W Q et al. 99Tc-methylene diphosphonate treatment is safe and efficacious for osteoporosis in postmenopausal differentiated thyroid cancer patients undergoing TSH suppression: a three-center non-randomized clinical study[J]. Cancer Management and Research, 14, 995-1005(2022).

[6] Su D L, Shen M N, Gu B J et al. 99Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral γδ T cells and CD4+ CD25+ Foxp3+ Tregs[J]. International Journal of Rheumatic Diseases, 19, 586-593(2016).

[7] Smetanin M, Vasilenko E K, Scherpelz R I. Mayak film dosimeter response studies, Part III: application to worker dose assessment[J]. Health Physics, 93, 239-244(2007).

[8] Lai K B, Jin C J, Tu S et al. Intravitreal injection of 99Tc-MDP inhibits the development of laser-induced choroidal neovascularization in rhesus monkeys[J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 252, 1049-1057(2014).

[9] Black D M, Delmas P D, Eastell R et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis[J]. The New England Journal of Medicine, 356, 1809-1822(2007).

[10] YAN Wei, WANG Zhonghan, LIU He. Action mechanism of bone remodeling imbalance in osteoporosis and relevant medical treatment strategy[J]. Chinese Journal of Tissue Engineering Research, 24, 4866-4874(2020).

[11] Zhao Y H, Wang L, Liu Y et al. Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw[J]. Calcified Tissue International, 91, 400-408(2012).

[12] CAO Min, LI Yaming, DIAO Yao et al. Advances in the diagnosis and treatment of bone related diseases by bisphosphonates[J]. International Journal of Radiation Medicine and Nuclear Medicine, 44, 119-124(2020).

[13] Wang L M, Gu Q R, Xu Y et al. Effects of yunke (technetium-99 conjugated with methylene diphosphonate; 99Tc-mdp) and/or colloidal chromic phosphate phosphonium-32, alone and in combination, in rats with adjuvant arthritis[J]. Clinical and Experimental Pharmacology and Physiology, 35, 23-28(2008).

[14] MU Rong, CHEN Shi, LI Zhanguo. Therapeutic effect of 99mTc-MDP and its role in proinflammatory cytokines in rheumatoid arthritis[J]. Chinese Journal of Rheumatology, 1, 39-41(2004).

[15] Chen J, Lan Y Y, He Y et al. 99Tc-MDP-induced human osteoblast proliferation, differentiation and expression of osteoprotegerin[J]. Molecular Medicine Reports, 16, 1801-1809(2017).

[16] ZHAO Guoding, GAO Kejia, TIAN Yingmin et al. Experimental study of Gukangling Decoction combined with technetium[99Tc] methylene diphosphonate injection in treating osteoporotic rabbits[J]. Journal of Integrative Medicine, 6, 298-303(2008).

Get PDF(in Chinese)

Figures&Tables (5)

References (16)

Copy Citation Text

Shengnan REN, Linlin LI, Yun ZHANG, Yaling ZHOU, Tao JIANG, Kejia GAO, Fang FENG. Preclinical evaluation of osteogenic effects of ⁹⁹Tc-MDP in osteoporosis models[J]. NUCLEAR TECHNIQUES, 2025, 48(3): 030302

Download Citation

Save the article for my favorites

Paper Information

Recommended Topics

laser devices and laser physics

Lasers and Laser Optics

laser manufacturing

Instrumentation, Measurement and Metrology

Set citation alerts for the article

Please enter your email address