Shengnan REN, Linlin LI, Yun ZHANG, Yaling ZHOU, Tao JIANG, Kejia GAO, Fang FENG. Preclinical evaluation of osteogenic effects of 99Tc-MDP in osteoporosis models[J]. NUCLEAR TECHNIQUES, 2025, 48(3): 030302

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- NUCLEAR TECHNIQUES
- Vol. 48, Issue 3, 030302 (2025)

Fig. 1. Dynamic changes of blood indexes and the protocol of 99Tc-MDP treatment of osteoporosis model(a) Blood calcium, (b) Blood phosphorus, (c) CTX-I, (d) P1NP, (e) Protocol of 99Tc-MDP treatment

Fig. 2. Variation of bone density illustrated in imaging (a~d) For SPECT/CT at 4 weeks, (e) 99Tcm-MDP uptake of knee joint was quantified, (f~i) For SPECT/HRCT at 8 weeks, 99Tcm-MDP uptake (j) and CT values (k) of knee joint were quantified, where A is negative control group, B is model control group, C is 99Tc-MDP treatment group, D is zoledronic acid treatment group

Fig. 3. Changes of blood calcium level (a) and blood phosphorus content (b) during the treatment of osteoporosis (color online) where A is negative control group, B is model control group, C is 99Tc-MDP treatment group, D is zoledronic acid treatment group

Fig. 4. Diagrams of imbalance and re-balance of OB/OC (color online). The quantification of distance between green and red fluorescence (a), area of stained OB (b) and intensity of stained OB (c), and typical fluorescence, IHC staining of ALP and TRAP, and HE staining were summarized in (d), where A is negative control group, B is model control group, C is 99Tc-MDP treatment group, D is zoledronic acid treatment group
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Table 1. Multi-cytokine analysis

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