Due to the unique nonlinear optical properties, quantum dot draws an extensive attention in the field of laser protection. However, the nonlinear optical effect of quantum dots is greatly undermined by its feature of easy clustering and transmutation. To solve this problem, the method of fabricating the CdxZn1-xSe/polymethylmethacrylate (PMMA) has been researched, and Z-scan technique has been used to conduct a research on the nonlinear optical properties of the fabricated CdxZn1-xSe/PMMA quantum dot organic polymer composite under a condition of 532 nm laser. The results show that with the Methyl methacrylate (MMA) as a polymer monomer, and Benzoyl peroxide (BPO) as an initiator, a uniform, stable and transparent CdxZn1-xSe/PMMA quantum dot organic glass has been successfully fabricated by using a modified blending method. The best three order nonlinear absorption and refraction coefficients are respectively achieved 7.90×10-8 m/W and -0.99×10-8 esu, and nonlinear properties is notable. Thus, the CdxZn1-xSe/PMMA quantum dot organic polymer composites have important and potential value in laser protection.