The indoor visible light communication system under the fluorescence interference is tested experimentally. The time-domain waveform of the received signal under fluorescence interference for the indoor visible light communication system modulated by on-off keying (OOK) modulation is obtained. Then a transmission baseband model and a 5 m×5 m×3 m indoor three-dimensional model are used to obtain the indoor bit error rate distribution. The influence of fluorescence interference on the performance of indoor visible light communication receivers is analyzed. The results show that the fluorescence interference is in the form of additive noise in the received signal, which leads to sinusoidal periodic signal distortion of the received signal. The fluorescence interference spectrum covers a wide range, and signals with a transmission rate of 10-1000 Mbit/s are affected. The signal is denoised by wavelet transform. The results show that the scale flexibility of wavelet transform can eliminate the fluorescence interference.