In order to improve abilities of human vision for situation perceiving and the recognition rate of the targets in gray scale image, a color transfer method of luminance remapping with multi-parameters was proposed to colorize the gray scale image. First, the RGB color spaces of the gray scale target image and the color reference image were converted to the YCbCr color space, in which the luminance value and color were separated. Then, the parameters which depended on the number of columns and luminance values of the color reference image and the gray scale target image were introduced. The luminance values of the color reference image were calculated to ensure the color reference image and the gray scale target image have the same range of luminance values. At last, according to the correlation of the neighborhood, each pixel of gray scale target image was matched with the pixel of the color reference image. The matched result was converted inversely to the RGB color space, which can represent a variety of colors. The occurrence of color misinformation is decreased in color transfer method of luminance remapping with multi-parameters. The accuracy degree of the color transfer is increased. At the same time, the running time of the program is reduced.