Aiming at optimal detonation controlling of directional warhead fuze, detonation control simulation for dodecagon-detection laser fuze was presented. Based on dodecagon-detection model, the detonation orientation was controlled by discriminating target orientation. Combining with target vulnerability model, effect of delay time on damage was simulated and analyzed on different trajectories. The simulation results show that it is very important to match the parameters such as fuze delay time, miss distance and fragment fly scattering angle for high-speed small targets in air. When delay time is no more than 2 ms, the average damage probability, if miss distance is within 8 m, is more than 0.6, and is less than 0.5 if miss distance is over 10 m. The model can comprehensively analyze the damage effects with different delay time and miss distances.