A non-zero dispersion-shifted fiber with core-depressed profile for large capacity and high bit rate backbone network and metropolitan area network is designed and fabricated by plasma chemical vapor deposition (PCVD) process. The designed fiber has the effective-core-area of more than 95 μm2 and the dispersion of about 9 ps/(nm·km) at 1550 nm, which can suppress the nonlinearity on the transmission system effectively. Meanwhile, the attenuation at 1550 nm is reduced to around 0.21 dB/km, and the splice loss with conventional single mode fiber is less than 0.11 dB while keeping the good bending performance (bending loss is less than 0.02 dB/km on the wavelength range from 1460 nm to 1625 nm with 60 mm bending diameter and 100 turns). The fiber also has a low dispersion slope of less than 0.065 ps/(nm2·km) and a low polarization mode dispersion (PMD) of less than 0.05 ps·km-1/2. Furthermore, the fiber can be used on the S-band (1460～1530 nm), C-band (1530～1565 nm) and L-band (1565～1625 nm) for wavelength division multiplexing (WDM) system because the zero-dispersion wavelength is shifted to lower than 1430 nm.