As precision guided weapons, missiles have been widely used in the battlefield, and corresponding countermeasures are also developing rapidly. Infrared decoy has become an important factor affecting the combat effectiveness of the guided missile with photoelectric seeker. In order to study the anti-decoy jamming ability of infrared self-homing missile, the physical effect environment of missile flight under the condition of infrared decoy jamming is constructed by using hardware-in-the-loop simulation system, and the anti-infrared decoy jamming ability of missile is analyzed in this paper. Through the hardware-in-the-loop simulation test, it can be seen that setting the distance between target and decoy properly can induce infrared guided missile to attack stationary target. For maneuvering target, if the decoy is placed at the right time, it can effectively induce infrared guided missile attack.