Plastic fiber has advantages over the conventional quartz fiber on respect of cost, fiber to the home application and short-distance communications. The plastic fiber amplifier can be gotten by doping the optical gain media such as quantum dots (QD) into plastic fiber. However, there is few study reported on the QD-doped plastic fiber. CdSe QD doped PMMA fiber material (CdSe/PMMA) is prepared. The UV-vis-near-infrared spectrum shows a narrow-size distribution of the CdSe QD in the CdSe/PMMA. The photoluminescence (PL) spectrum of the CdSe/PMMA is widen (about 10 nm) compared with the plain CdSe QD. Irradiated by a 473 nm laser for about 12 h, the PL peak intensity of the CdSe/PMMA is enhanced (about 1 time), and the peak wavelength shows a blue shift with 25 nm. Obtained results suggest that the CdSe/PMMA may be available fiber materials used as broadband amplifiers in the future.