• Journal of Radiation Research and Radiation Processing
  • Vol. 40, Issue 6, 060301 (2022)
Huichao LI1, Mingjuan ZHAO2, and Long TIAN1、*
Author Affiliations
  • 1The First Affiliated Hospital of Hebei Northern University, Zhangjiakou 075000, China
  • 2Hebei General Hospital, Shijiazhuang 050000, China
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    DOI: 10.11889/j.1000-3436.2022-0040 Cite this Article
    Huichao LI, Mingjuan ZHAO, Long TIAN. Study on the therapeutic mechanism and effect of metformin combined with single high-dose radiotherapy in mice with non-small cell lung cancer[J]. Journal of Radiation Research and Radiation Processing, 2022, 40(6): 060301 Copy Citation Text show less
    Survival curves of A549 cell in invitro test: (a) cell survival rate in different glucose concentrations medium under aerobic condition; (b) cell survival rate in different glucose concentrations medium under anaerobic condition
    Fig. 1. Survival curves of A549 cell in invitro test: (a) cell survival rate in different glucose concentrations medium under aerobic condition; (b) cell survival rate in different glucose concentrations medium under anaerobic condition
    Curves of tumor volume of mice along with time (at 42 d, the sequence from high to low is the group of Am, Bm, Cm, Dm, Em)
    Fig. 2. Curves of tumor volume of mice along with time (at 42 d, the sequence from high to low is the group of Am, Bm, Cm, Dm, Em
    Results of tracer in mice tumor area (at 6 min, the sequence from high to low is the group of Am, Bm, Cm, Dm, Em)
    Fig. 3. Results of tracer in mice tumor area (at 6 min, the sequence from high to low is the group of Am, Bm, Cm, Dm, Em)
    HE staining of tumor tissues of mice in each group (×400): (a) control group; (b) metformin alone group; (c) radiotherapy alone group; (d) metformin 1 h before radiotherapy group; (e) metformin 24 h after radiotherapy group
    Fig. 4. HE staining of tumor tissues of mice in each group (×400): (a) control group; (b) metformin alone group; (c) radiotherapy alone group; (d) metformin 1 h before radiotherapy group; (e) metformin 24 h after radiotherapy group
    Huichao LI, Mingjuan ZHAO, Long TIAN. Study on the therapeutic mechanism and effect of metformin combined with single high-dose radiotherapy in mice with non-small cell lung cancer[J]. Journal of Radiation Research and Radiation Processing, 2022, 40(6): 060301
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