The electronic system design and practice is a basic comprehensive design experiment and an important practice link for electrical students. Aiming at the problems of separate experimental items, tense class hours and different demands for class hours of students with different abilities in offline teaching of electronic system design and practice course, a hybrid teaching system is proposed. It includes establishing experimental demonstration operation and error prone knowledge base, upgrading assessment methods, and combining online teaching with offline practice. The result shows that the relevant measures have achieved good results in the teaching of electronic system design and practice courses, which can meet the requirements of students with different abilities. It has a significant effect on improving students’ innovative practice ability and plays an important role in the connection between basic knowledge and professional knowledge points.