Research Progress on Photodynamic Therapy for Gastrointestinal Diseases

Jiawen Wang; Ge Hong; Tianjun Liu

doi:10.3788/LOP56.040001

Journals >Laser & Optoelectronics Progress >Volume 56 >Issue 4 >Page 040001 > Article

Laser & Optoelectronics Progress
Vol. 56, Issue 4, 040001 (2019)

Research Progress on Photodynamic Therapy for Gastrointestinal Diseases

Jiawen Wang¹, Ge Hong², and Tianjun Liu^2、*

Author Affiliations

¹ Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

² Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China

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DOI: 10.3788/LOP56.040001 Cite this Article Set citation alerts

Jiawen Wang, Ge Hong, Tianjun Liu. Research Progress on Photodynamic Therapy for Gastrointestinal Diseases[J]. Laser & Optoelectronics Progress, 2019, 56(4): 040001 Copy Citation Text

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Disease	Year	Photosensitizer	Cell line or bacterium	Reference
Gastric cancer	2011	H₂TFPC-SGlc	MKN28, MKN45, HT29, HCT116	Ref. [7]
Gastric cancer	2015	α-PhSPcZn	SGC-7901	Ref. [8]
Gastric cancer	2015	DTP	MGC-803, MGC803/PA	Ref. [9]
Gastric cancer	2016	5-ALA	MKN-45	Ref. [10]
Gastric cancer	2017	Trast:Porph	HER2-positive cell	Ref. [11]
Gastric cancer	2017	AE	SGC-7901	Ref. [12]
Gastric cancer	2018	F127-APoG₂@AlPcS	SGC-7901	Ref. [13]
Colon cancer	2009	DH-Ⅱ-24	HCT116	Ref. [14]
Colon cancer	2017	TiO₂-ZnPc	HT29	Ref. [15]
Colon cancer	2017	FA-Fe₂O₃	HCT116	Ref. [16]
Colon cancer	2013	HPPH-CD	Colon26	Ref. [17]
Rectal cancer	2013	TMP	HCT116	Ref. [18]
Colon cancer	2015	5-ALA	SW620	Ref. [19]
Colon cancer	2015	Ce6	SW620	Ref. [20]
Rectal cancer	2017	HY	HT-29, HCT116	Ref. [21-22]
Rectal cancer	2018	PpIX	HCT116	Ref. [23]
Colon cancer	2018	m-THPC	SW480, SW620	Ref. [24]
Colon cancer	2016	HY	HCT116, HCT8	Ref. [25]
Rectal cancer	2017	m-THPC	HCT116	Ref. [26]
Gastritis	2010	MB	HP26695	Ref. [27]
Gastritis	2013	PSM	HP	Ref. [28]
Enteritis	2016	Au NRs@SiO₂-ICG	Escherichia coli LF82	Ref. [29]

Table 1. In vitro study of PDT for gastrointestinal diseases

Disease	Year	Photosensitizer	Modeling cell	Modeling animal	Reference
Gastric cancer	2008	5-ALA	MGC-803	SPF nude mice	Ref. [30]
Gastric cancer	2010	Talaporfin	MKN-45	BALB/c nude mice	Ref. [31]
Gastric cancer	2011	H₂TFPC-SGlc	HT29, HT116	BALB/c nude mice	Ref. [7]
Gastric cancer	2018	G-Ce6	CT26	BALB/c nude mice	Ref. [32]
Gastric cancer	2013	5-ALA	MKN-45	BALB/c nude mice	Ref. [33]
Gastric cancer	2016	TPP	SGC-7901	BALB/c nude mice	Ref. [34]
Gastric cancer	2018	Ce6	MGC-803	BALB/c nude mice	Ref. [35]
Colon cancer	2011	HY	CT26	BALB/c nude mice	Ref. [36]
Colon cancer	2011	IY69	Colon26	BALB/c nude mice	Ref. [37]
Colon cancer	2011	5-ALA	Colon26	BALB/c nude mice	Ref. [38]
Colon cancer	2012	HMME	CT26	BALB/c nude mice	Ref. [39]
Colon cancer	2013	Fullerene	CT26-luc	BALB/c nude mice	Ref. [40]
Colon cancer	2013	Deuteporfin	HCT-116	BALB/c nude mice	Ref. [41]
Rectal cancer	2016	HMME	VX2	Rabbit	Ref. [42]
Colon cancer	2017	PS	SW620	SCID mice	Ref. [43]
Colon cancer	2018	m-THPC	HT-29	BALB/c nude mice	Ref. [44]
Gastritis	1996	MB, TBO, HpD, Pc, 5-ALA	HP	Adult ferret, waster mice	Ref. [45]
Gastritis	2002	TPyP	HP	Male ferret	Ref. [46]
Enteritis	2011	5-ALA	T-cell	SCID mice	Ref. [47]
Enteritis	2015	m-THPC	DSS	C57/BL/6 mice	Ref. [48]

Table 2. In vivo study of PDT for gastrointestinal diseases

Disease	Year	Number of patients	Photosensitizer	Reference
Gastric cancer	2008	22	5-ALA	Ref. [49]
Gastric cancer	2014	1	Talaporfin sodium	Ref. [50]
Gastric cancer	2018	47	Photofrin	Ref. [51]
Colorectal cancer	1986	14	HpD	Ref. [52]
Colorectal cancer	2005	24	MTHPBC	Ref. [53]
Colon cancer	2006	20	Photofrin	Ref. [54]
Colorectal cancer	2016	40	Photoffin	Ref. [55]
Colorectal cancer	2016	23	Photofrin	Ref. [56]
Colorectal cancer	2017	120	5-ALA, HPD	Ref. [57]
Gastritis	2002	13	5-ALA	Ref. [58]
Gastritis	2005	10	PpIX, coproporphyrin	Ref. [59]
Factitial proctitis	1998	3	HPD	Ref. [60]

Table 3. Clinical research of PDT for gastrointestinal diseases

Jiawen Wang, Ge Hong, Tianjun Liu. Research Progress on Photodynamic Therapy for Gastrointestinal Diseases[J]. Laser & Optoelectronics Progress, 2019, 56(4): 040001

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