PUMA PROMOTES BAX ACTIVATION IN A FOXO3a-DEPENDENT MANNER IN STS-INDUCED APOPTOSIS

YINGJIE ZHANG; DA XING

[1] S. E. Kern, K. W. Kinzler, A. Bruskin et al., “Identification of p53 as a sequence-specific DNA binding protein,” Science 252, 1708–1711 (1991).

[2] B. Vogelstein, D. Lane, A. J. Levine, “Surfing the p53 network,” Nature 408, 307–310 (2000).

[3] A. R. Clarke, C. A. Purdie, D. J. Harrison et al., “Thymocyte apoptosis induced by p53-dependent and independent pathways,” Nature 362, 849–852 (1993).

[4] A. Strasser, A. W. Harris, T. Jacks, S. Cory, “DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2,” Cell 79, 329–339 (1994).

[5] M. Stahl, P. F. Dijkers, G. J. Kops et al., “The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2,” J. Immunol. 168, 5024–5031 (2002).

[6] W. S. Chen, P. Z. Xu, K. Gottlob et al., “Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene,” Genes Dev. 15, 2203–2208 (2001).

[7] A. S. Kirshenbaum, S. W. Kessler, J. P. Goff, D. D. Metcalfe, “Demonstration of the origin of human mast cells from CD34 bone marrow progenitor cells,” J. Immunol. 146, 1410–1415 (1991).

[8] A. A. Irani, N. M. Schechter, S. S. Craig, G. DeBlois, L. B. Schwartz, “Two types of human mast cells that have distinct neutral protease compositions,” Proc. Natl. Acad. Sci. USA 83, 4464–4468 (1986).

[9] L. Enerback, “Mast cells in rat gastrointestinal mucosa, I: Effects of fixation,” Acta. Pathol. Microbiol. Scand. 66, 289–302 (1966).

[10] M. Ekoff, T. Kaufmann, M. Engstrom et al., “The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells,” Blood 110, 3209–3217 (2007).

[11] J. Yu, L. Zhang, B. Vogelstein et al., “PUMA induces the rapid apoptosis of colorectal cancer cells,” Mol. Cell. 7, 673–682 (2001).

[12] J. Han, C. Flemington, A. B. Houghton et al., “Expression of bbc3, a pro- apoptotic BH3-only gene, is regulated by diverse cell death and survival signals,” Proc. Natl. Acad. Sci. USA 98, 11318– 11323 (2001).

[13] K. Nakano, K. H. Vousden, “PUMA, a novel proapoptotic gene, is induced by p53,” Mol. Cell. 7, 683–694 (2001).

[14] Y. Zhang, D. Xing, L. Liu, “PUMA promotes bax translocation by both directly interacting with bax and competitive binding to Bcl-XL during UV-induced Apoptosis,” Mol. Biol. Cell. 20, 3077– 3087 (2009).

[15] A. Villunger, E. M. Michalak, L. Coultas et al., “p53 and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa,” Science 302, 1036–1038 (2003).

[16] M. Erlacher, E. M. Michalak, P. N. Kelly et al., “BH3-only proteins Puma and Bim arer ate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo,” Blood 106, 4131–4138 (2005).

[17] H. You, M. Pellegrini, K. Tsuchihara et al., “FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal,” J. Exp. Med. 203, 1657–1663 (2006).

[18] M. D. Kaeser, R. D. Iggo, “From the cover: Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo,” Proc. Natl. Acad. Sci. USA 99, 95–100 (2002).

[19] M. C. Wei, W. X. Zong, E. H. Cheng et al., “Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death,” Science 292(5517), 727–730 (2001).

[20] A. Gross, J. Jockel, M. C. Wei, S. J. Korsmeyer, “Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis,” EMBO J. 17(14), 3878–3885 (1998).

[21] L. Zhang, D. Xing, X. Gao, S.Wu, “Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway,” J. Cell. Phys. 219, 553–562 (2009).

[22] X. Wang, D. Xing, L. Liu, W. R. Chen, “BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis,” FEBS Lett. 583, 1873–1879 (2009).

[23] L. Liu, D. Xing, W. R. Chen et al., “Calpainmediated pathway dominates cisplatin-induced apoptosis in human lung adenocarcinoma cells as determined by real-time single cell analysis,” Int. J. Cancer 122, 2210–2222 (2008).

[24] Y. Wu, D. Xing, W. Chen, X. Wang, “Bid is not required for Bax translocation during UV-induced apoptosis,” Cell Signal. 19, 2468–2478 (2007).

[25] Y. Pei, D. Xing, X. Gao, L. Liu, T. Chen, “Real-time monitoring full length bid interacting with Bax during TNF-a-induced apoptosis,” Apoptosis 12, 1681– 1690 (2007).

[26] S. Cory, J. M. Adams, “The Bcl2 family: Regulators of the cellular life-ordeath switch,” Nat. Rev Cancer 2, 647–656 (2002).

[27] F. Tsuruta, N. Masuyama, Y. Gotoh, “The Phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria,” J. Biol. Chem. 277(46), 14040–14047 (2002).

[28] F. Zanella, A. Rosado, B. Garcia, A. Carnero, W. Link, “Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening,” Chembiochem 9, 2229–2237 (2008).

[29] D. S. Hwangbo, B. Gersham, M. P. Tu et al., “Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body,” Nature 429, 562–566 (2004).

[30] M. E. Giannakou, M. Goss, M. A. Junger et al., “Long-lived Drosophila with overexpressed dFOXO in adult fat body,” Science 305, 361 (2004).

[31] J. Gilley, P. J. Coffer, J. Ham, “FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons,” J. Cell. Biol. 162, 613–622 (2003).