The four-quadrant photoelectric inspection model is studied on the basis of the second atmospheric channel modulator for enhancing the four-quadrant photoelectric inspection adaptability of the atmospheric channel. Firstly, the conversion relations of natural resolution and division precision are discussed from error theory perspectives for the analysis of the axis detection system. Afterwards，through the analysis of restricted constraint condition of four-quadrant photoelectric inspection system in atmospheric channel, it is found that the signal-to-noise ratio (SNR) of the beacon light and axis offset are two main technical parameters affecting the electro-optical inspection system. Then a concept is presented that enhancing natural resolution optical-axis detection system can lower the sensitivity of the whole system to the atmospheric channel. Finally, the division precision of axis detection is found to be gravely affected by the atmospheric channel. Axis detection can still provide precision for wireless laser communication if the natural resolution of four-quadrant photoelectric inspection is enhanced.