In order to simplify the actuation scheme of on-orbit high resolution imaging of space camera, a dual actuation structure of active deformation mirror based on the form of variable thickness is proposed. First, according to the theory of elasticity, the theoretical relationship between the wavefront aberration representation method and the variable thickness of the deformed mirror is established, and the thickness distribution required by various aberration modes can be solved. Then, the effect of aberration compensation is quantitatively evaluated through structural modeling, finite element analysis, surface fitting calculation and optical performance evaluation. Finally, the structure scheme and the driving scheme of the variable thickness deformation mirror optical machine are designed. Two actuators are used to realize the correction of spherical aberration and astigmatism. The deformation experiment results show that the dual-actuated deformation mirror can produce better spherical aberration and astigmatism, avoid the impression effect, and effectively compensate its own machining error and wavefront error of optical system.