The real-time and high precision detection algorithm of the laser facula is proposed. This work has digitized 14 bit laser facula video with the high frequency and high sensitive CCD; analyzed the feature of the laser facula is analyzed, the laser facula region by top-three-neighborhood-region continuous-pixels numbering algorithm is detected after segmenting the facula region by the threshold; the reason of surplus facula in the whole laser facula region is analyzed. The surplus facula region with the average threshold algorithm is subtracted, the more accurate facula centroid (including the center of mass and the center of figure) is gotten, and made the flow of the facula detection from the video frame, named operation-serial algorithm, which solve the problem of that tranditional neighbored-frame-subtraction algorithm can not dectect the inverse facula frame and the continous facula frame when the centroids of the facula are different. The experimental result shows that the proposed algorithm can be used to the online and offline detection of real-time and high precision laser facula practically.