A novel method for a large number of multiplexing fiber-optic Fizeau sensors using coarse wavelength division multiplexing (CWDM) and spatial-frequency division multiplexing (SFDM) is proposed and demonstrated. A CWDM device is used to multiplex signals from different sensor channels occupying different wavelength regions divided by the CWDM. The structure and principle of multiplexing fiber-optic Fizeau sensor are described, and the effect and reduction of cross-talk resulted from the multiplexing are analyzed. More than 10 Fizeau sensors arranged in a single channel can be multiplexed by using SFDM due to the long cavity length of the Fizeau sensor. The experimental results show that a strain accuracy of 5 με is achieved. There is little cross-talk between adjacent CWDM channels and also between two adjacent Fizeau strain sensors with certain cavity length difference. This system improves the multiplexing capability of Fizeau strain sensors significantly. It is anticipated that such a sensor system could find important applications in smart materials and health monitoring for large structures.