• Journal of Inorganic Materials
  • Vol. 36, Issue 1, 9 (2021)
Xiaokun CHENG1、2, Yue ZHANG1, Haijun Lü1, Xinying LIU2, Senlin HOU3, and Aibing CHEN1、*
Author Affiliations
  • 1College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China
  • 2Institute for the Development of Energy for African Sustainability, University of South Africa, Private Bag X6, Johannesburg 1710, South Africa
  • 3The Second Hospital of Hebei Medical University, Bilio-Pancreatic Endoscopic Surgery Department, Shijiazhuang 050000, China
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    DOI: 10.15541/jim20200240 Cite this Article
    Xiaokun CHENG, Yue ZHANG, Haijun Lü, Xinying LIU, Senlin HOU, Aibing CHEN. Porous Carbon Nanomaterials Based Tumor Targeting Drug Delivery System: a Review[J]. Journal of Inorganic Materials, 2021, 36(1): 9 Copy Citation Text show less
    Schematic illustration of template method for synthesis of PCN[41]
    1. Schematic illustration of template method for synthesis of PCN[41]
    Schematic illustration of direct pyrolysis methods for synthesis of porous carbon nanomaterials (PCN) (a) Preparation of MOF and porous carbon (PC)[58]; (b) Preparation of PC from plant tissue[59]; (c) Preparation of PC from PAN-co-PPy[60]; (d) Preparation of PC from PMMA-co-PS[61]
    2. Schematic illustration of direct pyrolysis methods for synthesis of porous carbon nanomaterials (PCN) (a) Preparation of MOF and porous carbon (PC)[58]; (b) Preparation of PC from plant tissue[59]; (c) Preparation of PC from PAN-co-PPy[60]; (d) Preparation of PC from PMMA-co-PS[61]
    (a) Schematic illustration of the preparation of DOX and FA conjugate with f-PCN to form CB-DOX/FA, and (b) the loading of DOX inside the pores and at the surface of functionalized PCN (f-PCN)[71]
    3. (a) Schematic illustration of the preparation of DOX and FA conjugate with f-PCN to form CB-DOX/FA, and (b) the loading of DOX inside the pores and at the surface of functionalized PCN (f-PCN)[71]
    Schematic preparation of DOX loaded on oxide mesoporous carbon nanospheres (OMCN) and its channel capped by the interaction of π-π[75]
    4. Schematic preparation of DOX loaded on oxide mesoporous carbon nanospheres (OMCN) and its channel capped by the interaction of π-π[75]
    Schematic illustration of preparing combined administration of (a) hierarchical hybrid dual-pore core-shell mesoporous carbon@silica[81] and (b) PHCNs-PEI-PEG for drug and gene co-loading[82] DOX: doxorubicin; PEI; polyethyleneimine; PEG: poly (ethylene glycol); RF: resorcinlo-formaldehyde
    5. Schematic illustration of preparing combined administration of (a) hierarchical hybrid dual-pore core-shell mesoporous carbon@silica[81] and (b) PHCNs-PEI-PEG for drug and gene co-loading[82] DOX: doxorubicin; PEI; polyethyleneimine; PEG: poly (ethylene glycol); RF: resorcinlo-formaldehyde
    Schematic illustration of pH-responsive controlled release of ZnO-gated MCNs[87]
    6. Schematic illustration of pH-responsive controlled release of ZnO-gated MCNs[87]
    Schematic illustration of enzyme-responsive of porous carbon obtained from ZIF pyrolysis [35]
    7. Schematic illustration of enzyme-responsive of porous carbon obtained from ZIF pyrolysis [35]
    Schematic illustration of modified porous hollow carbon spheres and the photothermal therapy[98]
    8. Schematic illustration of modified porous hollow carbon spheres and the photothermal therapy[98]
    Schematic illustration of MCNs coated Fe3O4 nanoparticles and DOX loaded[102]
    9. Schematic illustration of MCNs coated Fe3O4 nanoparticles and DOX loaded[102]
    Schematic preparation of MCN responsive controlled release by pH and glutathione[105]
    10. Schematic preparation of MCN responsive controlled release by pH and glutathione[105]
    Schematic illustration of construction of pH and magnetic composite sensitive materials by flower-like porous carbon composite (FPCS)[106]
    11. Schematic illustration of construction of pH and magnetic composite sensitive materials by flower-like porous carbon composite (FPCS)[106]
    Schematic illustration of construction drug delivery by pH and magnetic composite sensitive[108]
    12. Schematic illustration of construction drug delivery by pH and magnetic composite sensitive[108]
    Schematic preparation of stimuli-responsive MHPCNs based drug delivery system for synergistic pH, glutathione and photothermal of tumor chemotherapy[110]
    13. Schematic preparation of stimuli-responsive MHPCNs based drug delivery system for synergistic pH, glutathione and photothermal of tumor chemotherapy[110]
    PreparationBasic stepsRef.
    Hard template methodImpregnate the preformed hard template with carbon source, then remove the template after pyrolysis at a high temperature[29-30]
    Soft template methodThrough surfactant assembly, the template is removed after pyrolysis at high temperature[31-33]
    Direct pyrolysis methodDirect pyrolysis of carbon precursors, such as MOF, biomass, ionic liquid or polymer[34-37]
    Chemical vapor deposition methodIntroducing two or more gaseous carbon precursors into the tubular quartz reactor, carbon materials obtained through pyrolysis[38-40]
    Table 1.

    多孔碳纳米材料的制备方法

    StructureResponse modesDrugs>啊.
    Porous carbon spherepHMitoxantrone HCl[87]
    Porous carbon spherepHDoxorubicin[26]
    Porous carbon sphereSpecific enzymeDoxorubicin[91]
    Porous carbon derived from ZIFSpecific enzymeMethylene blue[35]
    Porous carbon sphereRedox potentialDoxorubicin[93]
    Hollow porous carbon sphereNear infraredDoxorubicin[82]
    Porous carbon sphereNear infraredDoxorubicin[98]
    Porous carbon sphere coated with Fe3O4MagneticDoxorubicin[102]
    Mesoporous carbon spherepH-redox potentialDoxorubicin[104][105]
    Porous carbon spherepH-magneticDoxorubicin[106]
    Ordered mesoporous carbon spherepH-magneticDoxorubicin[107]
    Ordered mesoporous carbon spheres coated with Fe3O4Magnetic-near infraredDoxorubicin[108]
    Porous carbon spheres coated with Au and Fe3O4Magnetic-near infraredDoxorubicin[109]
    Hollow porous carbon spherepH-redox potential-near infraredDoxorubicin[110]
    Table 2.

    多孔碳纳米材料构建抗肿瘤药物靶向传递系统

    Xiaokun CHENG, Yue ZHANG, Haijun Lü, Xinying LIU, Senlin HOU, Aibing CHEN. Porous Carbon Nanomaterials Based Tumor Targeting Drug Delivery System: a Review[J]. Journal of Inorganic Materials, 2021, 36(1): 9
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