Hydrophobic four phenoxyphthalocyanine zinc (ZnTPPc) was prepared on the surface of hydrophilic ZnO nanomaterialson the indium tin oxide (ITO) conductive glasswith in-situ synthesis by using DBU as liquid phase Catalyst. ZnTPPc was cyclized with phenoxy phthalonitrile as a molecular fragment and unsaturated zinc ions with dumbbellshaped ZnO(ZnO ZDs) surface as a template. The structure of ZnTPPc molecule and the characteristics of photogenerated charge in ZnTPPc/ZnO interface were confirmed by a variety of characterization methods. The photocatalytic selectivity of ZnTPPc/ZnO for the degradation of hydrophobic phenol (PL) was quantitatively analyzed by using hydrophilic methylene blue (MB), hydrophobic (PL) and their mixtures. The results show that hydrophobic ZnTPPc is synthesized by in-situ method on ZnO surface, presenting a monomolecular layer. The hydrophobic PL was preferentially adsorbed by ZnTPPc, and the relative degradation efficiency of PL is 13 times as high as that of MB under visible light irradiation.