LIVE IMAGING OF EARLY DEVELOPMENTAL PROCESSES IN MAMMALIAN EMBRYOS WITH OPTICAL COHERENCE TOMOGRAPHY

KIRILL V. LARIN; IRINA V. LARINA; MICHAEL LIEBLING; MARY E. DICKINSON

[1] S. W. Ruffins, R. E. Jacobs, S. E. Fraser, “Towards a Tralfamadorian view of the embryo: Multidimensional imaging of development,” Curr. Opin. Neurobiol. 12, 580–586 (2002).

[2] J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sorensen, R. Baldock, D. Davidson, “Optical projection tomography as a tool for 3D microscopy and gene expression studies,” Science 296, 541–545 (2002).

[3] A. S. Forouhar, M. Liebling, A. Hickerson, A. Nasiraei-Moghaddam, H. J. Tsai, J. R. Hove, S. E. Fraser, M. E. Dickinson, M. Gharib, “The embryonic vertebrate heart tube is a dynamic suction pump,” Science 312, 751–753 (2006).

[4] M. Liebling, A. S. Forouhar,M. Gharib, S. E. Fraser, M. E. Dickinson, “Four-dimensional cardiac imaging in living embryos via postacquisition synchronization of nongated slice sequences,” J. Biomed. Opt. 10, 054001 (2005).

[5] M. Liebling, A. S. Forouhar, R. Wolleschensky, B. Zimmermann, R. Ankerhold, S. E. Fraser, M. Gharib, M. E. Dickinson, “Rapid threedimensional imaging and analysis of the beating embryonic heart reveals functional changes during development,” Dev. Dyn. 235, 2940–2948 (2006).

[6] E. A. Jones, M. H. Baron, S. E. Fraser, M. E. Dickinson, “Measuring hemodynamic changes during mammalian development,” Am. J. Physiol. Heart Circ. Physiol. 287, H1561–1569 (2004).

[7] E. A. Jones, D. Crotty, P. M. Kulesa, C. W. Waters, M. H. Baron, S. E. Fraser, M. E. Dickinson, “Dynamic in vivo imaging of postimplantation mammalian embryos using whole embryo culture,” Genesis 34, 228–235 (2002).

[8] J. L. Lucitti, E. A. Jones, C. Huang, J. Chen, S. E. Fraser, M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134, 3317–3326 (2007).

[9] S. A. Boppart, M. E. Brezinski, B. Bouma, G. Tearney, J. G. Fujimoto, “Investigation of developing embryonic morphology using optical coherence tomography,” Developmental Biology 177, 54–63 (1996).

[10] S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. USA 94, 4256– 4261 (1997).

[11] T. M. Yelbuz, M. A. Choma, L. Thrane, M. L. Kirby, J. A. Izatt, “Optical coherence tomography — A new high-resolution imaging technology to study cardiac development in chick embryos,” Circulation 106, 2771–2774 (2002).

[12] V. X. D. Yang, M. Gordon, E. Seng-Yue, S. Lo, B. Qi, J. Pekar, A. Mok, B. Wilson, I. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamics of Xenopus laevis,” Opt. Express 11, 1650–1658 (2003).

[13] M.W. Jenkins, F. Rothenberg, D. Roy, V. P. Nikolski, Z. Hu, M.Watanabe, D. L.Wilson, I. R. Efimov, A. M. Rollins, “4D embryonic cardiography using gated optical coherence tomography,” Opt. Express 14, 736–748 (2006).

[14] W. Luo, D. L. Marks, T. S. Ralston, S. A. Boppart, “Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system,” J. Biomed. Opt. 11, 021014 (2006).

[15] M. W. Jenkins, D. C. Adler, M. Gargesha, R. Huber, F. Rothenberg, J. Belding,M. Watanabe, D. L.Wilson, J. G. Fujimoto, A. M. Rollins, “Ultra-highspeed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier domain mode locked laser,” Opt. Express 15, 6251–6267 (2007).

[16] A. Mariampillai, B. A. Standish, N. R. Munce, C. Randall, G. Liu, J. Y. Jiang, A. E. Cable, I. A. Vitkin, V. X. D. Yang, “Doppler optical cardiogram gated 2D color flow imaging at 1000 fps and 4D in vivo visualization of embryonic heart at 45 fps on a swept source OCT system,” Opt. Express 15, 1627–1638 (2007).

[17] A. M. Davis, F. G. Rothenberg, N. Shepherd, J. A. Izatt, “In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development,” J. Opt. Soc. Am. A 25, 3134–3143 (2008).

[18] L. Kagemann, H. Ishikawa, J. Zou, P. Charukamnoetkanok, G. Wollstein, K. A. Townsend, M. L. Gabriele, N. Bahary, X. Wei, J. G. Fujimoto, J. S. Schuman, “Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos,” Mol. Vis. 14, 2157–2170 (2008).

[19] I. V. Larina, N. Sudheendran, M. Ghosn, J. Jiang, A. Cable, K. V. Larin, M. E. Dickinson, “Live imaging of blood flow in mammalian embryos using Doppler swept source optical coherence tomography,” J. Biomed. Opt. 13, 0605063 (2008).

[20] A. Bradu, L. Ma, J. W. Bloor, A. Podoleanu, “Dual optical coherence tomography/fluorescence microscopy for monitoring of Drosophila melanogaster larval heart,” Journal of Biophotonics, DOI: 10.1002/jbio.200910021 (2009).

[21] A. Davis, J. Izatt, F. Rothenberg, “Quantitative measurement of blood flow dynamics in embryonic vasculature using spectral Doppler velocimetry,” The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 292, 311–319 (2009).

[22] I.V. Larina, S. N. Ivers, S. H. Syed,M. E.Dickinson, K. V. Larin, “Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT,” Opt. Lett. 34, 986–988 (2009).

[23] W. Y. Oh, S. H. Yun, G. J. Tearney, B. E. Bouma, “115kHz tuning repetition rate ultrahighspeed wavelength-swept semiconductor laser,” Opt. Lett. 30, 3159–3161 (2005).

[24] R. Huber, D. C. Adler, V. J. Srinivasan, J. G. Fujimoto, “Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second,” Opt. Lett. 32, 2049–2051 (2007).

[25] R. Huber, M. Wojtkowski, J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14, 3225–3237 (2006).

[26] B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, J. G. Fujimoto, “Ultrahigh speed Spectral/Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16, 15149–15169 (2008).

[27] D. C. Adler, R. Huber, J. G. Fujimoto, “Phasesensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers,” Opt. Lett. 32, 626–628 (2007).

[28] V. V. Tuchin, Optical Clearing of Tissues and Blood, Vol. PM 154, Bellingham, WA: SPIE Press (2005).

[29] I. V. Larina, E. F. Carbajal, V. V. Tuchin, M. E. Dickinson, K. V. Larin, “Enhanced OCT imaging of embryonic tissue with optical clearing,” Laser Phys. Lett. 5, 476–480 (2008).