[1] F. M. Ashcroft, P. Proks, P. A. Smith, C. Amm¨al¨a, K. Bokvist, P. Rorsman, “Stimulus-secretion coupling in pancreatic beta cells,”J. Cell. Biochem. 55 (Suppl), 54–65 (1994)
[2] P. Rorsman, E. Renstrom, “Insulin granule dynamics in pancreatic beta cells,” Diabetologia 46, 1029– 1045 (2003)
[3] N. Gustavsson, Y. Lao, A. Maximov, J. Chuang, E. Kostromina, J. J. Repa, C. Li, G. K. Radda, T. C. Sudhof, W. Han, “Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice,” Proc. Natl. Acad. Sci. U.S.A. 105, 3992–3997 (2008)
[4] G. A. Rutter, “Visualising insulin secretion. The Minkowski lecture 2004,” Diabetologia 47, 1861– 1872 (2004)
[5] D. Porte, Jr., “Beta-cells in type II diabetes mellitus,” Diabetes 40, 166–180 (1991)
[6] R. Zick, A. Hammer, G. Otten, H. J. Mitzkat, “Rapid radioimmunoassay for insulin and its application in localizing occult insulinomas by intraoperative pancreatic vein catheterization,” Eur. J. Nucl. Med. 7, 85–87 (1982)
[7] M. J. MacDonald, J. P. Gapinski, “A rapid ELISA for measuring insulin in a large number of research samples,” Metabolism 38, 450–452 (1989)
[8] Y. M. Leung, I. Ahmed, L. Sheu, R. G. Tsushima, N. E. Diamant, M. Hara, “Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse,” Endocrinology 146, 4766–4775 (2005)
[9] G. Miesenbock, D. A. Deangelis, J. E. Rothman, “Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins,” Nature 394, 192–195 (1998)
[10] M. Ohara-Imaizumi, Y. Nakamichi, T. Tanaka, H. Katsuta, H. Ishida, S. Nagamatsu, “Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic β-cell line MIN6 using pHsensitive green fluorescent protein (pHluorin) and confocal laser microscopy,” Biochem. J. 363, 73–80 (2002)
[11] M. Ohara-Imaizumi, C. Nishiwaki, T. Kikuta, S. Nagai, Y. Nakamichi, S. Nagamatsu, “TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic β-cells: Different behaviour of granule motion between normal and Goto–Kakizaki diabetic rat β-cells,” Biochem. J. 381, 13–18 (2004)
[12] Z. Zhang, J. Lin, Y. Ma, S. Zeng, Q. Luo, “Activation of Caspases-3 noninvolved in the bystander effect of HSV-tk/GCV system,” J. Biomed. Opt. 13, 031209 (2008)
[13] J. Lu, Z. Zhang, J. Yang, J. Chu, P. Li, S. Zeng, Q. Luo, “Visualization of β-secretase cleavage in living cells using a genetically encoded surface-displayed FRET biosensor,” Biochem. Biophys. Res. Commun. 362, 25–30 (2007)
[14] J. Yang, Z. Zhang, J. Lin, J. Lu, B. Liu, S. Zeng, Q. Luo, “Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor,” Biochim. Biophys. Acta 1773, 400–407 (2007)
[15] J. Lin, Z. Zhang, J. Yang, S. Zeng, B. Liu, Q. Luo, “Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis,” J. Biomed. Opt. 11, 024011 (2006)
[16] A. Miyawaki, J. Llopis, R. Heim, J. M. McCaffery, J. A. Adams, M. Ikura, R. Y. Tsien, “Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin,” Nature 388, 882–887 (1997)
[17] M. Yang, E. Baranov, P. Jiang, F. X. Sun, X. M. Li, L. Li et al., “Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases,” Proc. Natl. Acad. Sci. U.S.A. 97, 1206–1211 (2000)
[18] T. Xiong, Z. Zhang, B. F. Liu, S. Zeng, Y. Chen, J. Chu, Q. Luo, “In vivo optical imaging of human adenoid cystic carcinoma cell metastasis,” Oral Oncol. 41, 709–715 (2005)
[19] N. C. Shaner, R. E. Campbell, P. A. Steinbach, B. N. Giepmans, A. E. Palmer, R. Y. Tsien, “Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein,” Nat. Biotechnol. 22, 1567–1572 (2004)
[20] D.Njus, P.A. Sehr,G.K.Radda, G.A. Ritchie, P. J. Seeley, “Phosphorus-31 nuclear magnetic resonance studies of active proton translocation in chromaffin granules,” Biochemistry 17, 4337–4343 (1978)
[21] A. E. Pouli, E. Emmanouilidou, C. Zhao, C. Wasmeier, J. C. Hutton, G. A. Rutter, “Secretorygranule dynamics visualized in vivo with a phogringreen fluorescent protein chimaera,” Biochem. J. 333, 193–199 (1998)
[22] S. Y. Park, X. Wang, Z. Chen, A. C. Powers, M. A. Magnuson, W. S. Head, D. W. Piston, G. I. Bell, “Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase,” Transgene 43, 80–86 (2005)
[23] W. Han, Y. K. Ng, D. Axelrod, E. S. Levitan, “Neuropeptide release by efficient recruitment of diffusing cytoplasmic secretory vesicles,” Proc. Natl. Acad. Sci. U.S.A. 96, 14577–14582 (1999)
[24] N. V. Burke, W. Han, D. Li, K. Takimoto, S. C. Watkins, E. S. Levitan, “Neuronal peptide release is limited by secretory granule mobility,” Neuron 19, 1095–1102 (1997)
[25] T. Lang, I. Wacker, J. Steyer, C. Kaether, I. Wunderlich, T. Soldati, H. H. Gerdes,W. Almers, “Ca2+- triggered peptide secretion in single cells imaged with green fluorescent protein and evanescent-wave microscopy,” Neuron 18, 857–863 (1997)
[26] D. Zenisek, J. A. Steyer, W. Almers, “Transport, capture and exocytosis of single synaptic vesicles at active zones,” Nature 406, 849–854 (2000)
[27] A. A. Elayat,M.M. Naggar,M. Tahir, “An immunocytochemical and morphometric study of the rat pancreatic islets,” J. Anat. 186, 629–637 (1995)
[28] T. C. Brelje, D. W. Scharp, R. L. Sorenson, “Threedimensional imaging of intact isolated islets of Langerhans with confocal microscopy,” Diabetes 38, 808–814 (1989)
[29] M. Brissova, M. J. Fowler,W. E. Nicholson, A. Chu, B. Hirshberg, D. M. Harlan, A. C. Powers, “Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy,” J. Histochem. Cytochem. 53, 1087–1097 (2005)
[30] M. Hara, X. Wang, T. Kawamura, V. P. Bindokas, R. F. Dizon, S. Y. Alcoser, M. A. Magnuson, G. I. Bell, “Transgenic mice with green fluorescent protein-labeled pancreatic β-cells,” Am. J. Physiol. Endocrinol. Metab. 284, E177–E183 (2003)
[31] M. Van De Winkel, D. Pipeleers, “Autofluorescenceactivated cell sorting of pancreatic islet cells: Purification of insulin-containing β-cells according to glucose-induced changes in cellular redox state,” Biochem. Biophys. Res. Commun. 114, 835–842 (1983)
[32] T. Kanno, S. O. Gopel, P. Rorsman, M. Wakui, “Cellular function in multicellular system for hormone-secretion: Electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet,” Neurosci. Res. 42, 79–90 (2002)
[33] N. A. Bright, J.Walters, C.Wasmeier, J. C. Hutton, “Targeting of a phogrin-green fluorescent protein chimaera to insulin secretory granules of pancreatic beta-cells in transgenic mice,” Diabetes Metab. 28, 3S29–S36 (2002).