In order to solve the contradiction that light emitting diode (LED) lighting sources with high color rendering index may still exist rich-blue light hazards, the spectral visual similarity model of test light source spectrum with the reference light source spectrum is established based on spectral luminous efficiency, color-resolution function and spectral response function. A method is proposed to design high photometric-colorimetric property LED synthetic light source according to spectral visual similarity parameter (RV). Using the D50, the standard light source recommended by Commission Internationale de L′Eclairage (CIE), as reference illuminant, with the LEDs of cold white, warm white, red, green, cyan and blue are combined. The lamp numbers of all kinds of LED combination are calculated by traverse optimization method. According to the requirement of RV＞96, it turns out that the corresponding color temperature range of LED synthetic light source is between 4000-7000 K, and the general color rendering index Ra＞95 are accordant with the requirements of high photometric-colorimetric property and health in illumination light sources. Which proves the rationality of the proposed method. The results also show that, by choosing CIE standard light source with different color temperatures as the reference illuminant, we can design high color rendering of white light with different color temperatures.