In view of the high porosity susceptibility in laser welded Ti₂AlNb/TC4 dissimilar alloy, different beam displacements are applied in laser welding of Ti-22Al-27Nb and Ti-6Al-4V alloy. The results show that porosity can be successfully suppressed when laser beam acts on Ti-22Al-27Nb alloy. The fusion zones consist of B2 and B2+ α′ when the beam acts on Ti-22Al-27N band Ti-6Al-4V alloy, respectively. The heat affected zone (HAZ) of Ti-22Al-27Nb is entirely composed of B2. A mixture of acicular α′ and primary α are formed in the HAZ of Ti- 6Al-4V alloy. Due to the second phase strengthening of acicular α′ in the fusion zone when laser acts on Ti-6Al- 4V alloy, the welded joint exhibits higher tensile strength and ductility compared with those produced when the beam acts on Ti-22Al-27Nb alloy or at the middle of two base metals.