A novel multi-resolution image fusion based on mathematical morphological filtering is proposed. This fusion scheme constructs the low-pass and high-pass filters with morphological opening and closing operators. The original image is then decomposed into 4-subband image pyramid and 4-subband direction contrast image pyramid. The image fusion is performed by the direction contrast and region standard deviation to get the fused 4-subband image pyramid. The final fused image is formed with the subband image reconstruction. The fusion experiments indicate this image fusion is superior to the traditional fusion based on the morphological pyramid, contrast pyramid and wavelet decomposition.