Aiming at the problems of insufficient coverage and poor timeliness of existing Electrocardiograph(ECG) and Phonocardiogram(PCG) monitors, a wireless transmission-based ECG and heart sound monitoring system design is proposed. The system consists of 64 monitoring nodes. Each node is composed of a sensor module, a conditioning acquisition module, a storage module, a main control management module, a communication module, and a power management module. Each node can respond to 12-lead ECG signals and HKY-06B PCG signal that are collected and transmitted synchronously, and the information is collected to the monitoring center and fed back in time to realize remote real-time monitoring and provide parameter basis for early diagnosis of cardiovascular diseases. This system is suitable for hospitals, communities, disaster rescue sites such as shelter hospitals, which greatly improves the work efficiency of medical staff while ensuring high reliability.